The Madonna di foligno is one of my favourite works of art by Raphael;  here we see the Virgin and Child appearing to St. John the Baptist, Francis, Jerome and Sigismondo de Conti.  Look how modern St. John the Baptist looks!  note the hand covering the head and can you see the lion.  The cherubim holding the tray is a lovely gesture and I have been thinking about this symbolism for a while now; either the tray is to bear the fruit or the tray is to be seen as a mirror reflecting the divinity.  I wrote this in symbolism of this painting;

Virgo represents the Womb, the custodian of the hidden spiritual life.
Pisces represents the Soul in the human form or personality.

Symbolised by the manifestation into earth of the Virgin Sophia and her Son Christ.
We can see how both Virgo and Pisces show us sacredness things hidden.
Virgo being the vessel for the Spirit and Pisces the Soul in the vessel of Spirit.

The macrocosm / universe representation;
Virgo represents the Earth and Pisces represents the Sun. This might symbolise the Sun traveling through Virgo the birth canal. The spirit of the sun is in the earth in a period of gestation and travails with birth pains before the actual birth is given.

The microcosm/individual  representation;
Virgo represents our bodies and Pisces represents our Soul. Our souls are enclosed within our body and goes through a period of maturing and growth before being strong enough to be released into the spirit of awakened consciousness.

The balance is the nurturing of the soul within the womb.